Rhobust™ > Adsorbent Design
Adsorbent Design
The choice of adsorbent for EBA processes has direct consequences for stability, flow rate, productivity and yield. Both adsorbent density and adsorbent size distribution are critical design parameters for process robustness and optimal performance.
Rhobust adsorbent beads are manufactured using agarose polymer, which is well known to the regulatory authorities and has been classified as safe for use for the biopharmaceutical and food/feed industries.
Manufactured in-house in certified clean rooms, that comply with ISO 14644 quality procedures, the agarose beads are cross-linked to give thermal stability but also to retain elasticity, for operational longevity, and an open pore structure.
Adsorbent Design | Density | Size Distribution
| Process flow rate | high density | » high flow rate |
| Productivity | high flow rate | » high productivity |
| Mass transfer kinetics | small particle diameter | » fast equilibration |
| Process robustness | high density adsorbents | » more stable beds |
| Degree of expansion | low expansion |
» low washing and elution volumes |
| Product yield | fast process | » minimal degradation |
| Product purity | inert solid phase | » minimal non-specific binding |
| Bead stability | bead composition | » minimal degradation |
Website by College Hill - Life Sciences
